Soul Crushing Anime or Manga?

What would you guys recommend for the following criteria?

I want something soul crushing but it comes as a surprise. I want it to sneak up on me and boom it hits me with the weight of 100 suns. I would love it having elements of mystery, adventure, psychological thriller, and/or romance. Also preferably more than a season but don’t mind if it isn’t. And preferably a finished manga but again also isn’t a deal breaker.

Edit: thanks for all the suggestions, appreciate it!