USB vs XLR Cable for Recording?

Is there any difference to the sound clarity if recording via USB vs using XLR cables into an audio interface?

I just got my FM3 and Im trying to set it up the best possible way for recording.

I have an Audio Interface that I use for Microphone and Roland E-Drum kit too, so i'm not sure I can also attach those to the FM3?

It might make sense to record via USB as that is going directly from source to computer?

Any help much appreciated!